Glucocorticoid decreases circulating osteoprotegerin (OPG): possible mechanism for glucocorticoid induced osteoporosis | Zendy

Nobuhiro Sasaki | Zendy; Eiji Kusano | Zendy; Yukio Ando | Zendy; Kazuki Yano | Zendy; Toshio Suda | Zendy; Yasushi Asano | Zendy

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Glucocorticoid decreases circulating osteoprotegerin (OPG): possible mechanism for glucocorticoid induced osteoporosis

Author(s) -

Nobuhiro Sasaki,

Eiji Kusano,

Yukio Ando,

Kazuki Yano,

Toshio Suda,

Yasushi Asano

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.3.479

Subject(s) - osteoprotegerin , medicine , glucocorticoid , osteoporosis , endocrinology , osteoclast , bone resorption , receptor , activator (genetics)

Osteoporosis is a well known side-effect of long-term treatment with glucocorticoids. However, the precise mechanism of this disorder is unclear. Recently, osteoprotegerin (OPG) [osteoclastogenesis inhibitory factor (OCIF)] has been identified as a novel cytokine, which inhibits differentiation and activation of osteoclast. In the present study, in order to clarify the roles of OPG in the development of glucocorticoid-induced osteoporosis, we measured circulating OPG before and after glucocorticoid therapy.

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