Open AccessHomocysteine and lipid peroxidation in haemodialysis: role of folinic acid and vitamin E
Author(s) -
Beatriz Bayés,
Mari Cruz Pastor,
Jordi Bonal,
Jordi Juncà,
R. Romero
Publication year - 2001
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/16.11.2172
Subject(s) - medicine , folinic acid , lipid peroxidation , malondialdehyde , ascorbic acid , homocysteine , antioxidant , hyperhomocysteinemia , vitamin , vitamin e , endocrinology , oxidative stress , biochemistry , chemistry , chemotherapy , food science , fluorouracil
Cardiovascular diseases are the leading cause of death in haemodialysis patients. Hyperhomocysteinaemia is an independent risk factor. Basic research has provided strong evidence that oxidation of low-density lipoprotein (LDL) plays an important role in the pathogenesis of atherosclerosis. Oxidative stress, lipid metabolism alterations, and hyperhomocysteinaemia observed in haemodialysis patients could induce increases in LDL oxidation. This study was designed to determine the effect of folinic acid on hyperhomocysteinaemia and to assess the antioxidant efficacy of folinic acid. The antioxidant effect of folinic acid was compared with that of vitamin E.
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