Effects of the somatostatin analogue octreotide on renal function in conscious diabetic rats | Zendy

Martin Bak | Zendy; Klaus Thomsen | Zendy; Allan Flyvbjerg | Zendy

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Effects of the somatostatin analogue octreotide on renal function in conscious diabetic rats

Author(s) -

Martin Bak,

Klaus Thomsen,

Allan Flyvbjerg

Publication year - 2001

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/16.10.2002

Subject(s) - medicine , octreotide , endocrinology , effective renal plasma flow , renal function , diabetes mellitus , somatostatin , renal hypertrophy , glomerular hyperfiltration , renal blood flow , filtration fraction , kidney , renal physiology , diabetic nephropathy

Studies performed during the last decade have indicated that growth hormone (GH) and insulin-like growth factors (IGFs) may mediate the early renal changes in diabetes mellitus, i.e. hypertrophy and hyperfiltration. This and other observations have led to the suggestion that GH/IGF inhibitors, such as long-acting somatostatin analogue (e.g. octreotide and lanreotide), may be useful in order to inhibit or prevent development of long-term diabetic complications.

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