TGF‐β1 down‐regulates inflammatory cytokine‐induced VCAM‐1 expression in cultured human glomerular endothelial cells | Zendy

SuKil Park | Zendy; Won Seok Yang | Zendy; Sang Koo Lee | Zendy; Hanjong Ahn | Zendy; Jung Sik Park | Zendy; Onyou Hwang | Zendy; Jae Dam Lee | Zendy

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TGF‐β1 down‐regulates inflammatory cytokine‐induced VCAM‐1 expression in cultured human glomerular endothelial cells

Author(s) -

SuKil Park,

Won Seok Yang,

Sang Koo Lee,

Hanjong Ahn,

Jung Sik Park,

Onyou Hwang,

Jae Dam Lee

Publication year - 2000

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/15.5.596

Subject(s) - vcam 1 , cytokine , cell adhesion molecule , tumor necrosis factor alpha , endothelial stem cell , medicine , transforming growth factor beta , endothelium , inflammation , endocrinology , microbiology and biotechnology , transforming growth factor , icam 1 , immunology , biology , in vitro , biochemistry

Endothelial cells are active participants in the processes controlling coagulation, inflammation and the immune response. Variations are recognized between endothelia isolated from different vascular beds as well as from different species. Though transforming growth factor-beta(1) (TGF-beta(1)) has been known to have an anti-inflammatory action, little is known about its effect on expression of cellular adhesion molecules during the inflammatory process in human glomerular endothelial cells. The aim of this study was to determine the effect of TGF-beta(1) on the inflammatory cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human glomerular endothelial cells.

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