Open AccessEffects of mycophenolic acid on human renal proximal and distal tubular cells in vitro
Author(s) -
Patrick C. Baer,
Stefan Gauer,
Ingeborg A. Hauser,
Jürgen E. Scherberich,
Helmut Geiger
Publication year - 2000
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/15.2.184
Subject(s) - mycophenolic acid , cytokine , mycophenolate , guanosine , medicine , microbiology and biotechnology , kidney , pharmacology , immunology , transplantation , biochemistry , endocrinology , biology
Mycophenolic acid has been shown to be effective for the prevention and treatment of renal allograft rejection. Rejection episodes were found to be associated with an infiltration of lymphocytes and macrophages/monocytes into the diseased kidney. Expression of RANTES, HLA-DR and ICAM-1 may be important for the pathogenesis of this leukocyte infiltration. Therefore the aim of this study was to evaluate the effect of the antiproliferative and immunosuppressive agent mycophenolic acid (MPA) on cell growth and cytokine-induced expression of RANTES, HLA-DR and ICAM-1 of highly purified proximal (PTC) and distal tubular cells (DTC) from human kidney.
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