Open AccessThe 825C/T polymorphism of the G‐protein subunit β3 does not influence blood pressure and renal function in kidney transplant recipients
Author(s) -
Rudolf P. Wüthrich,
Snjezana Cicvara,
Christa Booy,
Urs Widmer,
U Binswanger
Publication year - 2000
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/15.10.1663
Subject(s) - medicine , renal function , blood pressure , kidney , kidney transplant , protein subunit , polymorphism (computer science) , urology , kidney transplantation , endocrinology , gastroenterology , genetics , genotype , gene , biology
Recently, a polymorphism at position 825 (C-->T) of the cDNA that encodes the beta3 subunit of heterotrimeric G proteins (Gbeta3) was found to be associated with essential hypertension. The T allele leads to the formation of a truncated splice variant (Gbeta3-s) with enhanced activity, promoting hypertension. We examined whether the T allele had an influence on blood pressure (BP) and early renal function after renal transplantation.
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