Glomerulonephritis and sodium retention: enhancement of Na+/K+-ATPase activity in the collecting duct is shared by rats with puromycin induced nephrotic syndrome and mice with spontaneous lupus-like glomerulonephritis | Zendy

Einath Zolty | Zendy; Nabila Ibnou-Zekri | Zendy; Shozo Izui | Zendy; Eric Féraille | Zendy; H Favre | Zendy

Open Access

Glomerulonephritis and sodium retention: enhancement of Na+/K+-ATPase activity in the collecting duct is shared by rats with puromycin induced nephrotic syndrome and mice with spontaneous lupus-like glomerulonephritis

Author(s) -

Einath Zolty,

Nabila Ibnou-Zekri,

Shozo Izui,

Eric Féraille,

H Favre

Publication year - 1999

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/14.9.2192

Subject(s) - endocrinology , medicine , glomerulonephritis , lupus nephritis , nephron , puromycin , reabsorption , kidney , biology , microbiology and biotechnology , protein biosynthesis , disease

In rats with puromycin aminoglucoside-induced (PAN) nephrotic syndrome, micropuncture studies have localized the site of sodium retention to the collecting duct. We have confirmed this finding by demonstrating a two-fold increase in Na+/K+-ATPase activity specifically limited to the cortical collecting duct in PAN rats. To further define whether this phenomenon was dependent on the chemical induction of the nephrotic syndrome or was a general phenomenon observed in glomerulonephritis, we measured Na+/K+-ATPase activity in nephron segments from mice with spontaneous lupus-like nephritis.

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