N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats | Zendy

M. Tariq | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats

Author(s) -

M. Tariq

Publication year - 1999

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/14.4.923

Subject(s) - nephrotoxicity , medicine , blood urea nitrogen , lipid peroxidation , pharmacology , kidney , oxidative stress , creatinine , acetylcysteine , toxicity , renal function , antioxidant , chemistry , biochemistry

Cyclosporin (CsA) has played an important role in the improvement of solid-organ transplant patients and graft survival. However, nephrotoxicity due to CsA remains an important clinical challenge. The renal toxicity of CsA is attributed to reduced renal blood flow which leads to hypoxia reoxygenation injury accompanied by excessive generation of oxygen-derived free radicals (ODFR). N-acetyl-L-cysteine (NAC) is a highly potent antioxidant that has been shown to reduce ODFR injury. In this study an attempt was made to assess the effect of NAC on CsA-induced lipid peroxidation and nephrotoxicity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research