Human recombinant erythropoietin inhibits interleukin-1 -stimulated nitric oxide and cyclic guanosine monophosphate production in cultured rat vascular smooth-muscle cells | Zendy

Eiji Kusano | Zendy; Takayuki Akimoto | Zendy; Makoto Inoue | Zendy; Y. Masunaga | Zendy; T. Umino | Zendy; Shuichi Ono | Zendy; Yukio Ando | Zendy; Sumiko Homma | Zendy; Shigeaki Muto | Zendy; Norio Komatsu | Zendy; Yoshihide Asano | Zendy

Open Access

Human recombinant erythropoietin inhibits interleukin-1 -stimulated nitric oxide and cyclic guanosine monophosphate production in cultured rat vascular smooth-muscle cells

Author(s) -

Eiji Kusano,

Takayuki Akimoto,

Makoto Inoue,

Y. Masunaga,

T. Umino,

Shuichi Ono,

Yukio Ando,

Sumiko Homma,

Shigeaki Muto,

Norio Komatsu,

Yoshihide Asano

Publication year - 1999

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/14.3.597

Subject(s) - cyclic guanosine monophosphate , nitric oxide , sodium nitroprusside , erythropoietin , vascular smooth muscle , nitric oxide synthase , medicine , endocrinology , intracellular , nitrite , atrial natriuretic peptide , guanosine , biology , biochemistry , nitrate , ecology , smooth muscle

Recently rat vascular smooth-muscle cells (VSMC) have been shown to possess Epo receptor, and respond to various cytokines for producing nitric oxide (NO). In the present study we examined the effect of pharmacological dose of human recombinant erythropoietin (rHuEpo) on the IL-1beta-induced NO and cGMP production as well as inducible nitric oxide synthase (iNOS) in cultured rat VSMC.

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