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Reduced kidney transplant rejection rate and pharmacoeconomic advantage of mycophenolate mofetil
Author(s) -
R. Wüthrich
Publication year - 1999
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/14.2.394
Subject(s) - medicine , azathioprine , regimen , creatinine , transplantation , urology , mycophenolic acid , gastroenterology , mycophenolate , kidney transplantation , renal function , surgery , disease
Several multinational controlled clinical trials have shown that triple therapy immunosuppressive regimens which include mycophenolate mofetil (MMF), cyclosporin A (CSA) and steroids (S) are superior compared with conventional regimens which include azathioprine (AZA), CSA and S, mainly because MMF reduces the rate of acute rejection episodes in the first 6 months after kidney transplantation. Post-marketing studies are useful to evaluate the general applicability and costs of MMF-based immunosuppressive regimens.

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