Open AccessExposed peptide core of IgA1 hinge region in IgA nephropathy
Author(s) -
Tohru Kokubo
Publication year - 1999
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/14.1.81
Subject(s) - nephropathy , medicine , pathogenesis , peptide , neuraminidase , immunology , polyclonal antibodies , proteinuria , endocrinology , antibody , kidney , biochemistry , chemistry , diabetes mellitus , virus
The human IgA1 hinge region is a very unique O-linked glycopeptide, and its sialylation and galactosylation recently were reported to be defective in the serum IgA1 derived from patients with IgA nephropathy (IgAN). This study was performed to examine the underglycosylation of the IgA1 hinge region and consequent exposure of the peptide core in IgAN.
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