Open AccessCardiovascular abnormalities in ageing and in uraemia - only analogy or shared pathomechanisms?
Author(s) -
Kerstin Amann
Publication year - 1998
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/13.suppl_7.6
Subject(s) - elastin , medicine , ageing , uremia , cardiology , left ventricular hypertrophy , thickening , muscle hypertrophy , pulsatile flow , pathophysiology , pulse (music) , pathology , blood pressure , engineering , detector , electrical engineering , polymer science , chemistry
The analogies between the effects of ageing and of uraemia on the function and the structure of central elastic arteries and of the heart are striking. Qualitatively similar changes are seen in pulse contour, pulse wave velocity, and impedance and also similar structural abnormalities with wall thickening, diminished elastin, and increased collagen content. The altered 'Windkessel' function of central arteries in age and uraemia is one factor contributing to left ventricular hypertrophy.
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