In vivo and in vitro neurotoxic action of plasma ultrafiltrate from uraemic patients | Zendy

S. Cantaro | Zendy

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In vivo and in vitro neurotoxic action of plasma ultrafiltrate from uraemic patients

Author(s) -

S. Cantaro

Publication year - 1998

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/13.9.2288

Subject(s) - neurotoxicity , in vivo , sciatic nerve , nerve conduction velocity , medicine , in vitro , electrophysiology , compound muscle action potential , pharmacology , anesthesia , toxicity , chemistry , biochemistry , biology , microbiology and biotechnology

In order to investigate the aetiology of uraemic neuropathy, we evaluated the neurotoxic activity of plasma from uraemic patients. To this end we prepared a concentrate (1:1000) of 2-60 kDa MW compounds from paired filtration dialysis ultrafiltrate and evaluated its activity on peripheral nerve conduction in vivo and in vitro.

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