The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide | Zendy

Hanneke Buter | Zendy; M.H. Hemmelder | Zendy; Ger Jan Navis | Zendy; Paul E. de Jong | Zendy; Dick de Zeeuw | Zendy

Open Access

The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide

Author(s) -

Hanneke Buter,

M.H. Hemmelder,

Ger Jan Navis,

Paul E. de Jong,

Dick de Zeeuw

Publication year - 1998

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/13.7.1682

Subject(s) - hydrochlorothiazide , medicine , proteinuria , blood pressure , sodium , endocrinology , diuretic , urology , pharmacology , kidney , chemistry , organic chemistry

Dietary sodium restriction enhances the antiproteinuric and blood pressure lowering effect of ACE inhibition. In clinical practice, however, long-term compliance to a low-sodium diet may be difficult to obtain. We therefore investigated whether the blunting of the antiproteinuric and blood pressure lowering efficacy of ACE inhibition by high sodium intake can be restored by the addition of a diuretic.

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