Pharmacokinetics of pantoprazole in patients with end-stage renal failure | Zendy

Volker Kliem | Zendy

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Pharmacokinetics of pantoprazole in patients with end-stage renal failure

Author(s) -

Volker Kliem

Publication year - 1998

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/13.5.1189

Subject(s) - pantoprazole , medicine , pharmacokinetics , dialysis , urine , metabolite , renal function , pharmacology , creatinine , urology , endocrinology , gastroenterology , omeprazole

Pantoprazole is a selective inhibitor of the gastric H+/K+-ATPase with a low potential to interact with the cytochrome P450 enzyme system. Since pantoprazole is metabolized in the liver to metabolites which are mainly cleared by the renal route, it was the aim of this study to investigate its pharmacokinetics in patients with end-stage renal failure undergoing regular haemodialysis.

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