Open AccessTissue-type plasminogen activator activity in HIV-associated HUS
Author(s) -
M.N. Peraldi,
Caroline Maslo,
Jeannig Berrou,
Éric Rondeau,
Willy Rozenbaum,
Jean–Daniel Sraer
Publication year - 1998
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/13.4.919
Subject(s) - medicine , plasminogen activator , gastroenterology , creatinine , immunology , immunopathology , pathophysiology , betaherpesvirinae , t plasminogen activator , sida , renal function , viral disease , human immunodeficiency virus (hiv) , herpesviridae
In children, haemolytic uraemic syndrome (HUS) is associated with high plasma plasminogen activator inhibitor type 1 (PAI-1), which may contribute to the persistence of renal glomerular and arteriolar thrombi. HUS has been described in HIV-infected patients, but the pathophysiology of HUS in these patients is poorly understood. The aim of the study was to investigate plasma fibrinolytic activity in 18 patients with HIV-associated HUS.
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