Angiotensin-converting-enzyme insertion/deletion genotype and long-term renal allograft survival | Zendy

Joachim Beige | Zendy; G. Offermann | Zendy; A. Distler | Zendy; Arya M. Sharma | Zendy

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Angiotensin-converting-enzyme insertion/deletion genotype and long-term renal allograft survival

Author(s) -

Joachim Beige,

G. Offermann,

A. Distler,

Arya M. Sharma

Publication year - 1998

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/13.3.735

Subject(s) - medicine , nephropathy , angiotensin converting enzyme , genotype , renin–angiotensin system , kidney , angiotensin ii , diabetic nephropathy , endocrinology , transplantation , gastroenterology , immunology , diabetes mellitus , blood pressure , gene , biology , genetics

Increased activity of the renin-angiotensin system has been implicated in decreased long-term survival of renal allografts. Recent studies suggest that a deletion variant of the angiotensin-converting enzyme, associated with increased humoral and tissue activity of this enzyme, may be a risk factor for the development of diabetic nephropathy and the progression of IgA nephropathy. The present study was conducted to determine whether the deletion variant of the angiotensin-converting-enzyme gene influences the long-term outcome in renal-transplant recipients.

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