Open AccessApoE polymorphism and albuminuria in diabetes mellitus: a role for LDL in the development of nephropathy in NIDDM?
Author(s) -
Robert Boize,
PierreYves Benhamou,
P Corticelli,
Kita Valenti,
JeanLuc Bosson,
Serge Halimi
Publication year - 1998
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/13.1.72
Subject(s) - medicine , diabetes mellitus , nephropathy , albuminuria , diabetic nephropathy , endocrinology , retinopathy , proteinuria , gastroenterology , kidney
Chronic hyperglycaemia stands with diabetes duration as the main predicting factor for the development of nephropathy in insulin dependent diabetes mellitus (IDDM). In contrast, nephropathy in non-insulin-dependent diabetes mellitus (NIDDM) presents with a different natural history and, as well as atherosclerosis, can precede diabetes diagnosis and even the onset of patent hyperglycaemia. The role of lipid abnormalities in this matter remains debated.