Open AccessA calcium-channel blocker, amlodipine, attenuates insulin antinatriuresis but does not modulate insulin-mediated attenuation of cardiovascular reactivity in healthy man
Author(s) -
Peter Stenvinkel,
A. Ottosson-Seeberger,
Kristina Potočki,
Anders Alvestrand
Publication year - 1997
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/12.8.1600
Subject(s) - medicine , amlodipine , calcium channel blocker , insulin , calcium channel , endocrinology , insulin sensitivity , calcium , pharmacology , insulin resistance , blood pressure
Insulin exerts an antinatriuretic effect when administered acutely in vivo. Interestingly, insulin fails to reduce sodium excretion in rats receiving verapamil. The present study was undertaken in order to investigate whether the calcium-channel blocker amlodipine attenuates the antinatriuretic effect of insulin in humans.
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