Open AccessConcise clinical report. Late occurrence of cysts in autosomal dominant medullary cystic kidney disease
Author(s) -
H. P. H. Neumann,
Ingeborg Zäuner,
Brigitte Strahm,
Bernhard U. Bender,
P. Schollmeyer,
Ulrike Blum,
R Rohrbach,
Friedhelm Hildebrandt
Publication year - 1997
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/12.6.1242
Subject(s) - medicine , autosomal dominant polycystic kidney disease , medullary cavity , polycystic kidney disease , kidney , kidney disease , disease , differential diagnosis , pathology , stage (stratigraphy) , cystic kidney disease , pediatrics , paleontology , biology
Medullary cystic kidney disease (MCD) is characterized by multiple renal cysts at the corticomedullary boundary area, by autosomal dominant inheritance, and by onset of chronic renal failure in the third decade of life. We report on a family with three affected individuals of both sexes in two generations presenting with end-stage renal failure at age 22-31 years. Primarily diagnoses considered included unclassified hereditary nephropathy and autosomal dominant polycystic kidney disease. Careful evaluation of all findings, initiated after investigation of renal morphology with CT, revealed features characteristic for MCD and led to the final diagnosis of MCD. We conclude that MCD is an important differential diagnosis for polycystic kidney disease in young adults with end-stage renal failure. Establishing the correct diagnosis has considerable impact for genetic counselling.