Open AccessEvidence for adaptation of the entire PTH-calcium curve to sustained changes in the serum calcium in haemodialysis patients
Author(s) -
Maria J. Borrego,
Arnold J. Felsenfeld,
Alejandro MartínMalo,
Yolanda Almadén,
M. T. Concepcion,
Pedro Aljama,
Mariano Rodríguez
Publication year - 1997
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/12.3.505
Subject(s) - calcium , medicine , endocrinology , parathyroid hormone , calcium metabolism , hyperparathyroidism , dialysis , magnesium , hemodialysis , secondary hyperparathyroidism , chemistry , organic chemistry
Based on in vitro studies, the set point of calcium has often been considered to represent an intrinsic property of parathyroid gland function. However, in the dialysis patient, the serum calcium does not consistently reflect the magnitude of hyperparathyroidism; in addition, little information is available on whether the PTH-calcium curve is modified by sustained changes in the serum calcium. The present study in haemodialysis patients was designed to evaluate whether the set point of calcium and the dynamics of PTH secretion were modified by sustained changes in the serum calcium.
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