Open AccessAmlodipine prevents and reverses the elevation in [Ca2+]i and the impaired phagocytosis of PMNL of diabetic rats
Author(s) -
Nesli̇han Seyrek,
Wojciech Marcinkowski,
Miroslaw Smogorzewski,
TarekM Demerdash,
S. G. Massry
Publication year - 1997
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/12.2.265
Subject(s) - amlodipine , phagocytosis , medicine , diabetes mellitus , endocrinology , calcium , calcium channel blocker , streptozotocin , calcium in biology , basal (medicine) , immunology , blood pressure
High glucose concentration, through the activation of calcium channels, augments in vitro calcium entry into cells and leads to elevation in the basal levels of [Ca2+]i, the latter causes cell dysfunction.
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