Effect of treatment with simvastatin on serum cholestryl ester transfer in patients on dialysis
Author(s) -
Robert Walker,
W. H. F. Sutherland,
Heather Walker,
Stephen MacMahon,
Richard A. Robson
Publication year - 1997
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/12.1.87
Subject(s) - simvastatin , apolipoprotein b , medicine , endocrinology , sterol o acyltransferase , dialysis , cholesterylester transfer protein , cholesteryl ester , cholesterol , lipoprotein , reductase , chemistry , biochemistry , enzyme
Plasma cholesteryl ester transfer activity is increased in patients with chronic renal failure on dialysis who have elevated levels of apolipoprotein B (apoB)-containing lipoproteins. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor, reduces levels of these lipoproteins but the effect of treatment on cholesteryl ester transfer activity in patients on dialysis remains to be determined.
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