Photo-switching of vinylpyrene-substituted 2'-deoxyguanosine and its application | Zendy

Yoshio Saitō | Zendy; Yoshiki Takeuchi | Zendy; Katsuhiko Matsumoto | Zendy; N. Takahashi | Zendy; Asako Suzuki | Zendy; Isao Saito | Zendy

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Photo-switching of vinylpyrene-substituted 2'-deoxyguanosine and its application

Author(s) -

Yoshio Saitō,

Yoshiki Takeuchi,

Katsuhiko Matsumoto,

N. Takahashi,

Asako Suzuki,

Isao Saito

Publication year - 2009

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrp097

Subject(s) - isomerization , fluorescence , irradiation , photochemistry , chemistry , deoxyguanosine , molecule , dna , organic chemistry , catalysis , optics , biochemistry , physics , nuclear physics

We synthesized C8-vinylpyrene-substituted 2'-deoxyguanosine (VPy)G and studied the photoinduced reversible E-Z isomerization. When E-isomer was irradiated with visible light (>420 nm), E- to Z-isomerization took place very rapidly, while upon irradiation with UV-light ( approximately 365 nm), Z-isomer was converted to E-isomer. When Z-isomer was illuminated with 365- 400 nm light, no fluorescence was observed, while E-isomer showed a very strong fluorescence emission, indicating that (VPy)G could be a useful fluorescence switching molecule.

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