Development of new DNA triplex triads by using 5-substituted deoxycytidine
Author(s) -
Takashi Kanamori,
Hiroyuki Tsunoda,
A. Ohkubo,
Masayuki Sekine,
Kohji Seio
Publication year - 2009
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrp082
Subject(s) - nucleobase , pseudouridine , cytosine , dna , triad (sociology) , chemistry , stereochemistry , biochemistry , transfer rna , gene , rna , psychology , psychoanalysis
We developed a new artificial DNA triplex triad which has the adenine nucleobase in the first strand. This triplex triad (A-psi-C*) is composed of adenine, pseudouridine and 5-sudstituted cytosine as the 1st, 2nd and 3rd strand nucleobases, respectively. The molecular design and synthesis of the nucleobases for the 2nd and 3rd strand of the triplex are also described.
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