Open AccessSynthesis of exciton-controlled fluorescent probes for RNA imaging
Author(s) -
Shuji Ikeda,
Takeshi Kubota,
Hiroyuki Yanagisawa,
Masahiro Yuki,
Akimitsu Okamoto
Publication year - 2009
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrp078
Subject(s) - fluorescence , nuclease , rna , exciton , chemistry , biophysics , orange (colour) , photochemistry , optics , biochemistry , biology , dna , physics , gene , food science , quantum mechanics
The excitonic interaction of thiazole orange dyes is known to suppress fluorescence emission. We have developed hybridization-sensitive fluorescent probes utilizing the excitonic interaction of two thiazole orange dyes connected to the probes. Here, we report nuclease-resistant hybridization-sensitive probes for long-term intracellular RNA imaging.
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