Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization | Zendy

Kohji Seio | Zendy; K. Miyazaki | Zendy; Sayako Kurohagi | Zendy; Y. MASAKI | Zendy; Hiroyuki Tsunoda | Zendy; Akihiro Ohkubo | Zendy; Masayuki Sekine | Zendy

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Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization

Author(s) -

Kohji Seio,

K. Miyazaki,

Sayako Kurohagi,

Y. MASAKI,

Hiroyuki Tsunoda,

Akihiro Ohkubo,

Masayuki Sekine

Publication year - 2009

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrp007

Subject(s) - oligonucleotide , rna , computational biology , chemistry , microbiology and biotechnology , biology , biochemistry , gene

We have developed 2'-O-methyl-RNAs having phosphorylated cyclohexane at the 5' and/or 3'-terminal adenine. These 2'-O-methyl-RNAs formed less stable duplex with the longer target RNA than that with the short target RNA. We tried to improve the short-RNA selective hybridization property by the synthesis of 2'-O-methyl-RNAs having terminal guanine modifications.

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