Open AccessSynthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure
Author(s) -
Aiko Yahara,
M. Nishida,
Takeshi Baba,
Takuya Kodama,
Tadashi Imanishi,
Satoshi Obika
Publication year - 2009
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrp006
Subject(s) - monomer , urea , chemistry , nucleic acid , thermal stability , carbamate , polymer chemistry , organic chemistry , biochemistry , polymer
Three kinds of novel bridged nucleic acid (BNA) monomers bearing carbamate or urea bridged structures, were designed and synthesized. One of these monomers, a urea-type BNA monomer was successfully incorporated into oligodeoxynucleotides (ODNs), and properties of the ODNs were evaluated. The ODNs containing the urea-type BNA monomers showed RNA selective hybridizing profiles and significant enzymatic stability.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom