Open AccessSynthesis of new non-nucleosidic ligand building blocks for solid-phase oligonucleotide assembly
Author(s) -
Asif Jamil,
E. M. Zubin,
Dmitry A. Stetsenko
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn363
Subject(s) - phosphoramidite , bifunctional , oligonucleotide , solid phase synthesis , combinatorial chemistry , reagent , chemistry , monomer , ligand (biochemistry) , phase (matter) , organic chemistry , biochemistry , dna , polymer , receptor , catalysis , peptide
Synthesis of new non-nucleosidic building blocks that incorporate 2,2'-biquinoline is described. Starting from readily available bicinchoninic acid, the corresponding bifunctional monomeric reagents for solid-phase oligonucleotide synthesis, phosphoramidite and H-phosphonate, have been prepared. The compounds developed may be useful for the design of sequence-specific artificial nucleases.
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