Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of -Containing Arginine | Zendy

Takehiko Wada | Zendy; N. Sawa | Zendy; Haruo Sato | Zendy; Shiroh Futaki | Zendy; Yuji Inoue | Zendy

Open Access

Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of -Containing Arginine

Author(s) -

Takehiko Wada,

N. Sawa,

Haruo Sato,

Shiroh Futaki,

Yuji Inoue

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn340

Subject(s) - arginine , rna , residue (chemistry) , nucleobase , peptide , nucleic acid , chemistry , amino acid , side chain , biochemistry , hydrogen bond , lysine , nucleotide , stereochemistry , biophysics , combinatorial chemistry , biology , dna , organic chemistry , molecule , gene , polymer

A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These alpha-PRNA form stable sequence-specific complex with the complementary RNA.

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