Open AccessCrown ether ring-fused nucleosides: synthesis and conformational properties
Author(s) -
Cinzia Coppola,
Jennifer D’Onofrio,
Giovanni Di Fabio,
Lorenzo De Napoli,
Daniela Montesarchio
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn337
Subject(s) - ether , ribonucleoside , crown ether , ring (chemistry) , bicyclic molecule , chemistry , stereochemistry , ribose , combinatorial chemistry , organic chemistry , rna , biochemistry , ion , gene , enzyme
We here describe the synthesis of a series of novel bicyclic ribonucleoside derivatives, with 18-crown-6 ether moieties attached via their ribose 2- and 3- positions, as first examples of crown ether ring-fused nucleosides, to be evaluated as antiviral and/or antitumoral agents.
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