Biologically active 2-5A analogs containing 3'-O,4'-C-propylene adenosine as potent RNase L agonists | Zendy

Koji Morita | Zendy; Satoshi Obika | Zendy; Tadashi Imanishi | Zendy; Yukio Kitade | Zendy; Makoto Koizumi | Zendy

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Biologically active 2-5A analogs containing 3'-O,4'-C-propylene adenosine as potent RNase L agonists

Author(s) -

Koji Morita,

Satoshi Obika,

Tadashi Imanishi,

Yukio Kitade,

Makoto Koizumi

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn322

Subject(s) - adenosine , rnase p , exonuclease , chemistry , enzyme , stereochemistry , biochemistry , rna , gene , polymerase

Novel 2-5A analogs composed of 3'-O, 4'-C-alkylene adenosine were synthesized as potent RNase L activators. When we examined their properties, including their RNase L activating ability and their stability to exonuclease, we found that these 2-5A analogs showed high RNase L activation and high resistance to enzymatic degradation without the modification of an essential adenosine at the second position.

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