Base-Modified Ribonucleosides as Potential Anti-Hepatitis C virus Agents | Zendy

Alexander V. Ivanov | Zendy; Olga A. Smirnova | Zendy; Н. А. Голубева | Zendy; А. В. Иванов | Zendy; V. L. Tunitskaya | Zendy; A. V. Shipitsyn | Zendy; Liudmila A. Alexandrova | Zendy

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Base-Modified Ribonucleosides as Potential Anti-Hepatitis C virus Agents

Author(s) -

Alexander V. Ivanov,

Olga A. Smirnova,

Н. А. Голубева,

А. В. Иванов,

V. L. Tunitskaya,

A. V. Shipitsyn,

Liudmila A. Alexandrova

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn313

Subject(s) - ns5b , ribonucleoside , rna polymerase , hepatitis c virus , rna , chemistry , virology , helicase , biochemistry , biology , virus , hepacivirus , gene

Four novel series of base modified ribonucleoside analogues were synthesized and evaluated as potential anti-HCV agents. For two compounds notable anti-HCV activity was observed The triphosphates of bicyclic pyrimidine ribonucleosides were studied as substrates/inhibitors of HCV RNA-dependent RNA polymerase (RdRp, NS5B protein) and RNA helicase/NTPase (NS3 protein).

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