Open AccessSynthesis of Pyrimidine Analog of Fluoroneplanocin A as Potential Anti- HCV Agent
Author(s) -
H.-R. Lee,
Won Ho Kim,
AhYoung Park,
J.-A. Kang,
Pusoon Chun,
J. Ho Bae,
Lak Shin Jeong,
Hyung Ryong Moon
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn307
Subject(s) - stereoselectivity , chemistry , pyrimidine , combinatorial chemistry , nucleoside analogue , mitsunobu reaction , nucleoside , stereochemistry , catalysis , organic chemistry
N-hydroxycytosine nucleoside 3 was synthesized as potential anti-HCV agent, starting from D-ribose using an iodine-fluorine exchange reaction by a help of BuLi, a RCM reaction, a stereoselective reduction and a Mitsunobu reaction as the key steps.
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