Open AccessSynthesis and antiviral activity of novel derivatives of 2'- -C-methylcytidine
Author(s) -
Joanna Fogt,
Piotr Januszczyk,
Grzegorz Framski,
Taku Onishi,
Kunisuke Izawa,
Erik De Clercq,
Johan Neyts,
Jerzy Boryski
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn306
Subject(s) - pyrimidine , chemistry , virology , in vitro , flaviviridae , viral replication , virus , hepatitis c virus , nucleoside , stereochemistry , biology , biochemistry
A series of novel derivatives of 2'-C-beta-methylcytidine, involving nucleosides modified in the "upper part" of the pyrimidine base (N(4)- and/or 5-position), has been synthesized and evaluated for their inhibitory effect on in vitro replication of the hepatitis C virus and the yellow fever virus (both Flaviviridae).
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