Design and development of curcumin bioconjugates as antiviral agents | Zendy

Dinesh Rai | Zendy; Desh Deepak Yadav | Zendy; Jan Balzarini | Zendy; Erik De Clercq | Zendy; Rekha Singh | Zendy

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Design and development of curcumin bioconjugates as antiviral agents

Author(s) -

Dinesh Rai,

Desh Deepak Yadav,

Jan Balzarini,

Erik De Clercq,

Rekha Singh

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn303

Subject(s) - curcumin , chemistry , combinatorial chemistry , biochemistry

A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others.

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