Synthesis of N-1-alkyl analogues of cyclic inosine diphosphate ribose (cIDPR) by a new solid phase approach | Zendy

Giorgia Oliviero | Zendy; Stefano D’Errico | Zendy; Nicola Borbone | Zendy; Jussara Amato | Zendy; Vincenzo Piccialli | Zendy; Michela Varra | Zendy; Gennaro Piccialli | Zendy; Luciano Mayol | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis of N-1-alkyl analogues of cyclic inosine diphosphate ribose (cIDPR) by a new solid phase approach

Author(s) -

Giorgia Oliviero,

Stefano D’Errico,

Nicola Borbone,

Jussara Amato,

Vincenzo Piccialli,

Michela Varra,

Gennaro Piccialli,

Luciano Mayol

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn290

Subject(s) - inosine , chemistry , alkyl , pyrophosphate , stereochemistry , ribose , solid phase synthesis , combinatorial chemistry , polystyrene , agonist , organic chemistry , adenosine , biochemistry , polymer , receptor , enzyme , peptide

Herein we report an efficient solid-phase synthesis of some N-1-alkyl-substituted analogs of cyclic inosine-diphosphate-ribose (cIDPR), a mimic of cyclic ADP-ribose (cADPR) which has been described as an agonist of the cADPR/Ca(2+) signalling system. The proposed synthetic strategy uses a polystyrene support bearing inosine by a 2',3'-acetal linkage which is converted into several N-1-alkylinosine-bis-phosphate derivatives which in turn were cyclized by a solid-phase pyrophosphate bond formation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research