Improved Synthesis of Nucleoside Diphosphate Glycopyranoses

A new efficient method for the synthesis of nucleoside diphosphate glycopyranoses is based on cycloSal-approach. This new chemical synthesis uses cyclosaligenyl nucleoside phosphate triester as an active phosphate ester. In comparison with other known methods NDP sugars can be synthesised in short reaction times and convincing chemical yields. The method allows the preparation of anomerically pure NDP glycopyranoses.