Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini | Zendy

Y. Ueno | Zendy; Kenji Kawada | Zendy; Aya Shibata | Zendy; K. Yoshikawa | Zendy; Yusuke Wataya | Zendy; Yukio Kitade | Zendy

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Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini

Author(s) -

Y. Ueno,

Kenji Kawada,

Aya Shibata,

K. Yoshikawa,

Yusuke Wataya,

Yukio Kitade

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn255

Subject(s) - small interfering rna , gene silencing , chemistry , sense strand , sense (electronics) , rna interference , conjugated system , microbiology and biotechnology , biophysics , rna , biochemistry , biology , gene , polymer , organic chemistry

Short interfering RNAs (siRNAs) conjugated with lipophilic groups at their 3'-termini were synthesized. The silencing activities of these siRNAs were examined by a dual-luciferase assay. It was found that the '-end of the passenger strand (sense strand) was better than the guide strand (antisense strand) for connecting bulky lipophilic molecules, particularly a rigid molecule such as cholesterol.

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