Towards the Replication of xDNA, a Size-expanded Unnatural Genetic System | Zendy

Andrew T. Krueger | Zendy; Haiyu Lu | Zendy; Torben Højland | Zendy; H. Liu | Zendy; Jianmin Gao | Zendy; Eric T. Kool | Zendy

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Towards the Replication of xDNA, a Size-expanded Unnatural Genetic System

Author(s) -

Andrew T. Krueger,

Haiyu Lu,

Torben Højland,

H. Liu,

Jianmin Gao,

Eric T. Kool

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn231

Subject(s) - replication (statistics) , dna replication , biology , dna , genetics , computational biology , dna polymerase , virology

Here we study the viability of an unnatural genetic system with size-expanded geometry (xDNA). xDNA contains base pairs 2.4 A larger than those of natural DNA. The expanded geometry is expected to be problematic for the natural high-fidelity replication machinery required to process genetic information. However, initial studies with a variety of DNA polymerases are promising in demonstrating replication of these unnatural bases. The results suggest the future possible viability of fully functional unnatural genetic systems, and give insight into the steric limits of some natural DNA polymerases.

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