Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs | Zendy

Takeo Itô | Zendy; Akiko Kondo | Zendy; Aiko Hayashi | Zendy; T. UCHIDA | Zendy; Kazuhito Tanabe | Zendy; Satoshi Nishimoto | Zendy

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Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs

Author(s) -

Takeo Itô,

Akiko Kondo,

Aiko Hayashi,

T. UCHIDA,

Kazuhito Tanabe,

Satoshi Nishimoto

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn214

Subject(s) - dna , base pair , duplex (building) , chemistry , linker , photoinduced electron transfer , electron transfer , covalent bond , conjugated system , phenothiazine , stereochemistry , photochemistry , biology , biochemistry , polymer , organic chemistry , computer science , pharmacology , operating system

A series of DNA containing photoinduced electron donors and mismatched DNA base pairs have been prepared and applied for the chemical investigation of excess electron transfer (EET) in the duplex DNA. As the electron donors, phenothiazine (PTZ) with a flexible linker was tethered to the 5'-end or in the middle of the sequences, or diaminostilbene (DAS) was covalently linked to form a hairpin structure. The presence of mismatched base pair lowered EET efficiency in the DAS-capped DNA hairpins, on the other hand, efficient EET beyond the mismatch site was observed in the PTZ-conjugated DNA.

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