Exceptional Fluorescence and Hybridization Properties of a Phenylpyrrolocytosine in Peptide Nucleic Acid | Zendy

Filip Wojciechowski | Zendy; R. H.E. Hudson | Zendy

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Exceptional Fluorescence and Hybridization Properties of a Phenylpyrrolocytosine in Peptide Nucleic Acid

Author(s) -

Filip Wojciechowski,

R. H.E. Hudson

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn204

Subject(s) - fluorescence , peptide nucleic acid , nucleic acid , dna , nucleobase , chemistry , quantum yield , peptide , combinatorial chemistry , derivative (finance) , nucleic acid thermodynamics , biochemistry , stereochemistry , biophysics , biology , base sequence , physics , quantum mechanics , financial economics , economics

A phenylpyrrolocytosine derivative possessing bis-(ortho-aminoethoxy) substitution has been designed, synthesized and incorporated into PNA resulting in oligomers that demonstrate increased binding affinity for DNA targets. The phenylpyrrolocytosine is an exceptionally fluorescent modified nucleobase possessing a high quantum yield while the fluorescence intensity displays useful environmental sensitivity.

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