Synthesis of the Peptide Nucleic Acid (PNA) Incorporating 2-Amino-6-vinylpurine Derivative and Evaluation of the Reactivity | Zendy

Shion Imoto | Zendy; A. Shimotazawa | Zendy; Tomoya Hirohama | Zendy; Masahiro Goto | Zendy; Fumi Nagatsugi | Zendy

Open Access

Synthesis of the Peptide Nucleic Acid (PNA) Incorporating 2-Amino-6-vinylpurine Derivative and Evaluation of the Reactivity

Author(s) -

Shion Imoto,

A. Shimotazawa,

Tomoya Hirohama,

Masahiro Goto,

Fumi Nagatsugi

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn199

Subject(s) - nucleic acid , reactivity (psychology) , chemistry , nucleoside , peptide nucleic acid , peptide , combinatorial chemistry , amino acid , dna , derivative (finance) , cytosine , selectivity , nucleic acid thermodynamics , biochemistry , stereochemistry , catalysis , base sequence , medicine , alternative medicine , pathology , financial economics , economics

Previously, we established a new strategy of synchronous cross linking reaction activated by hybridization to target genes. In this strategy, the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, is generated from its stable precursors by a hybridization-promoted activation process with selectivity to cytosine. In this paper, we wish to report the synthesis of the peptide nucleic acids (PNAs) incorporating 2-amino-6-vinylpurine derivatives and the evaluation of their reactivity to target DNA.

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