Circular DNA Formation on the Bimolecular Triplex of Anthracene-modified Oligonucleotide Conjugate | Zendy

Paola Arslan | Zendy; Toshihiro Ihara | Zendy; Akinori Jyo | Zendy

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Circular DNA Formation on the Bimolecular Triplex of Anthracene-modified Oligonucleotide Conjugate

Author(s) -

Paola Arslan,

Toshihiro Ihara,

Akinori Jyo

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn198

Subject(s) - conjugate , dna , oligonucleotide , anthracene , chemistry , triple helix , helix (gastropod) , biophysics , stereochemistry , biochemistry , photochemistry , biology , mathematical analysis , ecology , mathematics , snail

DNA is usually found in nature as a double stranded helix but there are many other structural forms that it can adopt. Triple helical DNA structures are one of these arrangements that DNA can form through some folding interactions. These structures have attracted great interest in the field of DNA recognition due to their higher affinity and selectivity. Here we introduced a bimolecular triplex structure formed by a anthracene-DNA conjugate through a well characterized photodimerization reaction in the presence of complementary target and evaluated the system for the target discrimination by using a mismatch target. Results indicated that the system could provide moderate discrimination.

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