Open AccessHydrolysis of Single Linkage in Long DNA using Oligonucleotide-Multiphosphonate Conjugates and CeIV/EDTA
Author(s) -
Yuta Suzuki,
Tuomas Lönnberg,
Makoto Komiyama
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn192
Subject(s) - oligonucleotide , conjugate , dna , chemistry , hydrolysis , combinatorial chemistry , linkage (software) , biochemistry , stereochemistry , gene , mathematics , mathematical analysis
Only one phosphodiester linkage in long DNA was hydrolyzed simply by using two components: oligonucleotide-multiphosphonate conjugates ("gapmers") and Ce(IV)/EDTA (Fig. 1).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom