DNA Glue: 1-, 2- and 4-Ethynylpyrenes in the Structure of Twisted Intercalating Nucleic Acids (TINAs), DNA Duplexes/Triplexes and Interstrand Excimer Formation | Zendy

Vyacheslav V. Filichev | Zendy; Kira Astakhova | Zendy; A. D. Malakhov | Zendy; Vladimir A. Korshun | Zendy; Erik B. Pedersen | Zendy

Open Access

DNA Glue: 1-, 2- and 4-Ethynylpyrenes in the Structure of Twisted Intercalating Nucleic Acids (TINAs), DNA Duplexes/Triplexes and Interstrand Excimer Formation

Author(s) -

Vyacheslav V. Filichev,

Kira Astakhova,

A. D. Malakhov,

Vladimir A. Korshun,

Erik B. Pedersen

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn175

Subject(s) - antiparallel (mathematics) , dna , duplex (building) , chemistry , excimer , nucleic acid , intercalation (chemistry) , stereochemistry , biophysics , crystallography , biochemistry , fluorescence , biology , physics , quantum mechanics , magnetic field , inorganic chemistry

Significant alterations in thermal stability of parallel DNA triplexes and antiparallel duplexes were observed upon changing the attachment of ethynylpyrenes from para to ortho in the structure of phenylmethylglycerol inserted as a bulge into DNA (TINA). Insertions of two ortho-TINAs as a pseudo-pair in the middle of the duplex resulted in formation of an excimer band at 505 nm for both 1- and 4-ethynylpyrene analogues.

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