A versatile synthetic approach for the development of libraries of 5', 3'-bis-conjugated oligonucleotides | Zendy

Giovanni Di Fabio | Zendy; Cinzia Coppola | Zendy; Jennifer D’Onofrio | Zendy; Lorenzo De Napoli | Zendy; Daniela Montesarchio | Zendy

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A versatile synthetic approach for the development of libraries of 5', 3'-bis-conjugated oligonucleotides

Author(s) -

Giovanni Di Fabio,

Cinzia Coppola,

Jennifer D’Onofrio,

Lorenzo De Napoli,

Daniela Montesarchio

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn151

Subject(s) - conjugated system , oligonucleotide , combinatorial chemistry , nucleoside , chemistry , nanotechnology , computational biology , computer science , stereochemistry , materials science , biology , dna , biochemistry , organic chemistry , polymer

A versatile approach to develop libraries of diverse 5',3'-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming d((5')TGGGAG(3')) sequence, as a potential anti-HIV agent, has been here used as a model system.

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