Synthesis of a Photoresponsive -Dideoxyuridine Triphosphate Derivative | Zendy

Yoko Nitta | Zendy; Masayuki Ogino | Zendy; Y. Yoshimura | Zendy; Kenzo Fujimoto | Zendy

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Synthesis of a Photoresponsive -Dideoxyuridine Triphosphate Derivative

Author(s) -

Yoko Nitta,

Masayuki Ogino,

Y. Yoshimura,

Kenzo Fujimoto

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn148

Subject(s) - dna , chemistry , dna synthesis , derivative (finance) , transferase , ligation , enzyme , biochemistry , microbiology and biotechnology , combinatorial chemistry , biology , financial economics , economics

The synthesis of a photoresponsive alpha-5-cyanovinyl- 2',3'-dideoxyuridine-5'-triphosphate (alpha dd(C)UTP) is described. A one-pot enzymatic synthesis of photoresponsive alpha-5-cyanovinyl-2',3'-dideoxyuridine (alpha dd(C)U) labeled ODNs with terminal deoxynucleotideyl transferase (TdT) would be a powerful tool for the development of modified long-chain DNA and branched DNA unable to be prepared by DNA synthesizer or enzymatic ligation.

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