Open Accessm7GTP S is a strong and stable inhibitor of cap-dependent translation
Author(s) -
Joanna Kowalska,
Maciej Łukaszewicz,
Joanna Zuberek,
Marcin Ziemniak,
Malwina Strenkowska,
Edward Darżynkiewicz,
Jacek Jemielity
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn147
Subject(s) - diastereomer , eif4e , translation (biology) , potency , chemistry , eukaryotic translation , stereochemistry , messenger rna , biochemistry , in vitro , gene
Two diastereomers of 7-methylguanosine 5'-O-(1-thiotriphosphate) have been synthesized and resolved by RP HPLC. Preliminary studies revealed that these new analogs of mRNA cap are characterized by high affinity for eIF4E, resistance towards DcpS pyrophosphatase and high potency to inhibit cap-dependent translation.
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