Synthesis and Properties of Oligonucleotides Containing Silylated Pyrene Derivatives | Zendy

Tomohisa Moriguchi | Zendy; M. Hattori | Zendy; Tohru Sekiguchi | Zendy; Mayumi Ichimura | Zendy; Tsuyoshi Kato | Zendy; Kazuo Shinozuka | Zendy

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Synthesis and Properties of Oligonucleotides Containing Silylated Pyrene Derivatives

Author(s) -

Tomohisa Moriguchi,

M. Hattori,

Tohru Sekiguchi,

Mayumi Ichimura,

Tsuyoshi Kato,

Kazuo Shinozuka

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn129

Subject(s) - pyrene , oligonucleotide , chemistry , duplex (building) , fluorescence , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , dna , physics , quantum mechanics

Preparation and properties of the novel fluorescently labelled oligonucleotides, containing the silylated pyrene derivatives are reported. The silylated pyrene derivatives were introduced into both 5'-terminus and C-5 position of the deoxyuridine derivatives. The fluorescent spectra indicated the possibility of the discrimination of the duplex formation by the simple denaturation.

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